Jesse was born in 1750 in Gretna, Pittsylvania, VA, the son of Thomas Mustain and Mary Haley.
He died in JUN 1794 in Gretna, Pittsylvania Co., VA..
His wife was Jenny Unknown, who he married in ABT 1776. The place has not been found. Their eight known children were Susanna (1785->1840), Tabitha (1777-<1850), Thomas (1778-1814), Priscilla (1778-1850), Jesse Jr. (1780-?), John (1782-1869), James W (c1787-1850) and Winifred (1791-1829).